Mfg Part Number
Ab00442-10.3
Vector Labs Ab00442-10.3 Anti-Glycoprotein D of HSV [E317], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
Herpes simplex virus 1.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | E317 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Envelope glycoprotein D; gD |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IP; Blocking |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody binds specifically to the glycoprotein D of HSV. The epitope core structure maps to the external surface of gD, corresponding to the binding sites of two receptors, herpesvirus entry mediator (HVEM) and nectin-1, which mediate HSV infection. E317 directly recognizes the gD-nectin-1 interface and occludes the HVEM contact site of gD to block its binding to either receptor. The binding of E317 to gD also prohibits the formation of the N-terminal hairpin of gD for HVEM recognition. The major E317-binding site on gD overlaps with either the nectin-1-binding residues or the neutralizing antigenic sites identified thus far (Tyr38, Asp215, Arg222 and Phe223). The epitopes of gD for E317 binding are highly conserved between two types of human herpesvirus (HSV-1 and HSV-2). |
| Application Notes: | This antibody binds to glycoprotein D of HSV and blocks its intereaction with human cellular receptors. Glycoprotein D binds to cell entry receptors TNFRSF14/HVEM and others, triggering fusion with the host membrane. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |