Mfg Part Number
Ab00447-1.1
Vector Labs Ab00447-1.1 Anti-CD40L [hu5c8 (Ruplizumab)], Mouse IgG1, kappa (200 μg)
Quick Overview
Human CD40L
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | hu5c8 (Ruplizumab) |
| Synonyms: | CD154; CD40 ligand; tumour necrosis factor ligand superfamily member 5; TNFSF5; tumour necrosis factor related activation protein; TRAP |
| Amount: | 200 μg |
| Application Codes Clone: | Block; FC; WB |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 11525169 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to CD40L with an IC50 of 0.845 ug/ml. |
| Application Notes: | The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531 ± 155 hours. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |