Mfg Part Number
Ab00448-1.1
Vector Labs Ab00448-1.1 Anti-TNF alpha [CDP 571 (Humicade)], Mouse IgG1, kappa (200 μg)
Quick Overview
Human TNF-alpha
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CDP 571 (Humicade) |
| Synonyms: | TNFA; Tumour necrosis factor superfamily member 2; TNFSF2 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; NTRL |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 7558164 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to human TNF-alpha with a Kd of 0.087 nM. |
| Application Notes: | The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |