Mfg Part Number
Ab00450-1.1
Vector Labs Ab00450-1.1 Anti-CD4 [CE9.1 (Clenoliximab)], Mouse IgG1, lambda (200 μg)
Quick Overview
Domain 1 of human CD4.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | CE9.1 (Clenoliximab) |
| Synonyms: | p55; T cell surface antign T4/Leu-3. |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC; Block; SPR; IHC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 1369023 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 (primatized) |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG4 (primatized) format, for improved compatibility with existing reagents, assays and techniqu |
| Specificity Statement: | The antibody binds to human CD4 with a Kd of 1.0 nM and an ED50 of 0.2 ug/ml. |
| Application Notes: | The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |