Mfg Part Number
Ab00467-1.1
Vector Labs Ab00467-1.1 Anti-763.74 [MK2-23], Mouse IgG1, kappa (200 μg)
Quick Overview
Monoclonal antibody 763.74.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | MK2-23 |
| Synonyms: | Ab763.74 idiotype; High molecular weight-associated melanoma antigen-neutralising antibody 763.74 (anti-idiotype) |
| Amount: | 200 μg |
| Application Codes Clone: | Block |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 16227204 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse format, for improved compatibility with existing reagents, assays and techniques. |
| Application Notes: | The antibody binds specifically to the monoclonal antibody 763.74. The 763.74 antibody has neutralising activity against HMW-MAA, a cell surface proteoglycan expressed on more than 90% of melanomas, which has been shown to contribute to the malignant transformation of cancer cells by inducing their invasion, growth and migration. The anti-idiotypic monoclonal antibody MK2-23 mimics HMW-MAA in the binding to 763.67, and can thereby increase the level of antibody production against the antigen in patients with the melanoma. This induces a humoral immune response which has caused the regression of melanomas in some patients and can prolong their survival. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |