Mfg Part Number
Ab00475-10.7
Vector Labs Ab00475-10.7 Anti-CD30 [Ki-4], Human F(ab)2, AbFab2™ His-Tagged, kappa (200 μg)
Quick Overview
Human CD30.
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | Ki-4 |
| Heavy Chain Modification: | AbFab2™ His-Tagged |
| Synonyms: | TNFRSF8; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC; IHC; IF; inhibit |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to CD30. |
| Application Notes: | The antibody binds specifically to CD30, a cell membrane protein which belongs to the tumour necrosis factor receptor family. Incubation of CD30 positive L540 cells with Ki-4 antibody completely inhibits release of soluble CD30 (in contrast to Ki-3, Ab00474). CD30 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |