Mfg Part Number
Ab00481-10.7
Vector Labs Ab00481-10.7 Anti-BACE2 [1/ 9 ], Human F(ab)2, AbFab2™ His-Tagged, kappa (200 μg)
Quick Overview
Human BACE2 244–333.
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 1/ 9 |
| Heavy Chain Modification: | AbFab2™ His-Tagged |
| Synonyms: | Beta-secretase 2; Aspartic-like protease; Aspartyl protease 1; Asp1; Beta-site amyloid precursor protein cleaving enzyme 2; Down syndrome aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; theta-secretase |
| Amount: | 200 μg |
| Application Codes Clone: | WB; IHC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 23695257 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Application Notes: | The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |