Mfg Part Number
Ab00483-10.6
Vector Labs Ab00483-10.6 Anti-LTC4 [mAbLTC], Human Fab fragment, His-Tagged, kappa (200 μg)
Quick Overview
Human LTC4.
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | mAbLTC |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | Leukotriene C4 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; RIA; Block |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 20079714 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to LTC4 with an EC50 of 0.11 μM. |
| Application Notes: | The antibody binds specifically to LTC4, a member of eicosanoid inflammatory mediators synthesised from arachidonic acid by arachidonate 5-lipoxygenase. LTC4 is a cysteynyl-leukotriene, and acts at the cell-surface receptors CysLT1 and CysLT2, which are both G-protein coupled receptors (GPCRs) involved in human bronchial asthma. LTC4 is responsible for increasing airway responsiveness to histamine in asthmatic patients, and antibodies that block this activity can be used in the treatment of inflammatory diseases such as asthma, and to inhibit platelet aggregation. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |