Mfg Part Number
Ab00484-10.6
Vector Labs Ab00484-10.6 Anti-PGE2 [mAbPGE], Human Fab fragment, His-Tagged, kappa (200 μg)
Quick Overview
Human PGE2.
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | mAbPGE |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | Prostaglandin E2 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; RIA |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 20079714 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Application Notes: | The antibody binds specifically to PGE2, a lipid compound synthesised from the oxidation of arachidonic acid by cyclooxygenases (COX-1 and COX-2), and from the action of prostaglandin E synthase on prostaglandin H2. PGE2 is an important inflammatory mediator and homeostatic factor that acts on the receptors EP1, EP2 and EP3, which are all members of the family of G-protein coupled receptors (GPCRs). The neutralisation of PGE2 by the use of monoclonal antibodies provides an alternative to the use of NSAIDs in the treatment of acute and chronic inflammatory diseases such as rheumatoid arthritis. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |