Mfg Part Number
Ab00485-23.0
Vector Labs Ab00485-23.0 Anti-Progesterone [DB3], Rabbit IgG, kappa (200 μg)
Quick Overview
11-a-hydroxyprogesterone-11-hemisuccinyl-bovine serum albumin (BSA) conjugate.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | DB3 |
| Synonyms: | P4; D |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IHC; Block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds progesterone with an affinity (Kd) of 1 nM. |
| Application Notes: | The antibody binds specifically to progesterone, a steroid female sex hormone produced by the corpus luteum in the ovaries, and then by the placenta during pregnancy. The hormone is necessary for maintenance of pregnancy as it prevents the breakdown of the endometrium. Monoclonal antibodies against progesterone can be useful to increase the understanding of the role of the hormone in the female reproductive system, and may be potentially used as an immunological prevention of pregnancy. Studies have shown that the injection of DB3 in female mice had anti-fertility effects. It is thought that DB3 may inhibit pregnancy by binding to a progesterone transport protein, thereby preventing the uptake of progesterone by epithelial cells of the uterine tissue. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |