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Mfg Part Number

Ab00495-10.6

Vector Labs Ab00495-10.6 Anti-LeX [291-2G3-A], Human Fab fragment, His-Tagged, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was obtained from mice infected with schistosomes.

$595.40

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Description

Product Class: Purified
Clone ID: 291-2G3-A
Heavy Chain Modification: His-Tagged
Synonyms: Sialyl Lewis X; SLeX; Stage-specific embryonic antigen 1; SSEA-1; CD15
Amount: 200 μg
Application Codes Clone: IHC; ICC
Shipping Temperature: Wet Ice
Origin Pub PMID: 15242599
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG3
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: The antibody binds to Lewis X trisaccharide, a carbohydrade pivotal in mediating specific cell-cell interactions, with an affinity of 11 μM.
Application Notes: The antibody binds specifically to Lewis X, a tetrasaccharide carbohydrate blood-group antigen involved in cell-to-cell adhesion. The antigen is involved in human fertilisation, as it is present on the terminus of N- and O-glycans of the zona pellucida of egg cells, which are recognised by sperm cells This interaction allows fusion and fertilisation to occur. LeX also plays a role in leukocyte tethering as they travel through the bloodstream as it can interact with L-selectin, P-selectin and E-selectin. LeX is also present on neutrophils, mediating phagocytosis and chemotaxis, and is expressed in patients with Hodgkin disease, B-cell chronic lymphocytic leukemia, acute lymphoblastic leukemias and acute nonlymphocytic leukemia. It is also expressed as SSEA-1 on mouse embryonic stem cells. LeX also plays a role in human resistance to the parasitic disease schistosomiasis.

Product Class:	Purified
Clone ID:	291-2G3-A
Heavy Chain Modification:	His-Tagged
Synonyms:	Sialyl Lewis X; SLeX; Stage-specific embryonic antigen 1; SSEA-1; CD15
Amount:	200 μg
Application Codes Clone:	IHC; ICC
Shipping Temperature:	Wet Ice
Origin Pub PMID:	15242599
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG3
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	The antibody binds to Lewis X trisaccharide, a carbohydrade pivotal in mediating specific cell-cell interactions, with an affinity of 11 μM.
Application Notes:	The antibody binds specifically to Lewis X, a tetrasaccharide carbohydrate blood-group antigen involved in cell-to-cell adhesion. The antigen is involved in human fertilisation, as it is present on the terminus of N- and O-glycans of the zona pellucida of egg cells, which are recognised by sperm cells This interaction allows fusion and fertilisation to occur. LeX also plays a role in leukocyte tethering as they travel through the bloodstream as it can interact with L-selectin, P-selectin and E-selectin. LeX is also present on neutrophils, mediating phagocytosis and chemotaxis, and is expressed in patients with Hodgkin disease, B-cell chronic lymphocytic leukemia, acute lymphoblastic leukemias and acute nonlymphocytic leukemia. It is also expressed as SSEA-1 on mouse embryonic stem cells. LeX also plays a role in human resistance to the parasitic disease schistosomiasis.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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