Mfg Part Number
Ab00507-24.1
Vector Labs Ab00507-24.1 Anti-Plasma cell antigen 1 [4G6], Goat IgG, kappa (200 μg)
Quick Overview
The original version of this antibody was raised by immunizing rats with MRL-lpr/lpr T cells.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 4G6 |
| Synonyms: | PC.1 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; WB; IF; FC; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric goat antibody was made using the variable domain sequences of the original Rat format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes the plasma cell antigen 1. |
| Application Notes: | The antibody binds specifically to PC.1, an antigen which is highly expressed on the surface of plasma cells and some non-lymphoid tissue. The antigen is involved with secretion or exocytosis of immunoglobulins from B cells, and may play a role in the secretion of lymphokines from lpr/lpr T cells. When the population of this subset of T cells expands, it accumulates in lymph nodes and results lymphadenopathy. Studies have shown that preventing this expansion by performing neonatal thymectomy delays the onset of systemic lupus erythematosus (SLE), suggesting that the T cells play a role in the development of the autoimmune disease. Monoclonal antibodies directed against PC.1 can be useful in the diagnosis and monitoring of SLE. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |