Mfg Part Number
Ab00511-10.7
Vector Labs Ab00511-10.7 Anti-Vaginolysin [9B4], Human F(ab)2, AbFab2™ His-Tagged, kappa (200 μg)
Quick Overview
Recombinant VLY.
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 9B4 |
| Heavy Chain Modification: | AbFab2™ His-Tagged |
| Synonyms: | VLY |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; WB; Block |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 22047084 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to VLY with an affinity (Kd) of 0.29 nM and an IC50 of 0.067 nM (determined by hemolytic assay). The antibody has a strong neutralizing capability. |
| Application Notes: | The antibody binds specifically to VLY, a pore-forming toxic member of the cholesterol-dependent cytolysins, produced by the bacterium Gardnerella vaginalis. Once released, VLY acts by binding to cholesterol-rich membranes and forming transmembrane pores that result in lysis of the cell. The bacterium G. vaginalis is predominant in the vaginal tract of women with bacterial vaginosis (BV). Here releases VLY toxins that cause cytolysis and tissue destruction, and potentially leading to serious adverse effects such as infertility. Antibodies that are able to neutralize the toxic activity of VLY can be used as therapeutic agents for the treatment of BV. The antibody 9B4 has the strongest neutralizing activity, and binds to an epitope region comprising of the amino acids 122 to 268 of VLY. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |