Mfg Part Number
Ab00516-10.6
Vector Labs Ab00516-10.6 Anti-Tissue factor [5G9], Human Fab fragment, His-Tagged, kappa (200 μg)
Quick Overview
Human TF.
$595.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 5G9 |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | TF; platelet tissue factor; factor III; thromboplastin; CD142 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; WB; Block |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 9480775 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Application Notes: | The antibody binds specifically to TF, a hemostatic protein which is involved in the extrinsic pathway of coagulation. TF is receptor for circulating serine protease factor VIIa, activating the catalytic VIIa protease domain. The complex formed functions to activate the zymogen factor X into activated factor Xa, which then catalyses the formation of Prothrombin to Thrombin. The pathways results in a fibrin clot which acts to stop bleeding. The monoclonal antibody 5G9 acts as a competitive inhibitor of factor X, thereby inhibiting its activation by the TF.VIIa complex and the formation of a clot. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |