Mfg Part Number
Ab00519-1.1
Vector Labs Ab00519-1.1 Anti-GPIIb/IIIa [10E5], Mouse IgG1, kappa (200 μg)
Quick Overview
Human blood platelets.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 10E5 |
| Synonyms: | CD41; Integrin alpha-IIb/beta-3; Glycoprotein IIb/IIIa; αIIbβ3 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; WB; IF |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 15378069 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 µg/ml. |
| Application Notes: | The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmann's thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |