Mfg Part Number
Ab00525-10.0
Vector Labs Ab00525-10.0 Anti-CA125 [196-14], Human IgG1, kappa (200 μg)
Quick Overview
HOUA-1 cells from endometrial cancer.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 196-14 |
| Synonyms: | MUC16; Cancer antigen 125; carcinoma antigen 125; carbohydrate antigen 125; mucin 16 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IHC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 7860092 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody binds to CA125 with a Kd of 0.83 nM reported for the original antibody. |
| Application Notes: | The antibody binds specifically to CA125, membrane associated glycoprotein which acts as a biomarker for ovarian cancer detection, and is also associated with endometrial, fallopian tube, lung, breast and gastrointestinal tract cancers. CA125 plays an important role in tumorigenesis by enhancing the metastasis of tumour cells, increasing immune system evasion, inducing motility and resistance to chemotherapy. The monoclonal antibody 196-14 can be used for both in vivo and in vitro applications, and potentially in the diagnosis and treatment of endometrial or ovarian cancers expressing high levels of CA125. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |