Mfg Part Number
Ab00559-8.1
Vector Labs Ab00559-8.1 Anti-CD2 [OX-34], Rat IgG2b, kappa (200 μg)
Quick Overview
OX-34 was prepared by immunizing mice with T blasts prepared in
mixed lymphocyte reactions with purified rat T helper cells against irradiated spleen.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | OX-34 |
| Synonyms: | LFA-2; LFA2; OX-34 antigen; OX34 antigen; T-cell surface antigen T11/Leu5; T cell surface antigen T11/Leu5; OX34; MRC OX34; MRC OX-34 |
| Amount: | 200 μg |
| Application Codes Clone: | block; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | OX-34 binds specifically to rat CD2. CD2 is type I membrane protein involved in triggering of T-cells (cytoplasmic domain is involved in signaling function) and is expressed on thymocytes, peripheral T cells, dendritic epidermal T cells, macrophages in the spleen, and NK cells. |
| Application Notes: | Ox34 blocks CD48 binding to CD2 causing partial block of T cell activation; OX34 can be used to deplete peripheral T cells (used to prevent allograft rejection in vivo). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |