Mfg Part Number
Ab00562-8.1
Vector Labs Ab00562-8.1 Anti-CD45RC [OX-22], Rat IgG2b, kappa (200 μg)
Quick Overview
OX-22 was prepared by immunizing BALB/c mice with phytohemagglutinin-activated rat lymph node cells.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | OX-22 |
| Synonyms: | L-CA; Receptor-type tyrosine-protein phosphatase C; leukocyte common antigen; T200; CD45; OX22; MRC OX22; MRC OX-22; CD45 R |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IHC; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rat antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | OX-22 binds specifically to the high molecular weight form of the leucocyte common antigen, CD45RC. OX-22 and OX-31 compete for binding but do not compete with OX-32. The antigen is expresssed on the surface of B cells, around half of bone marrow cells, all CD8+ve T cells, and is able to differentiate between CD4+CD45RChigh (Th1-like) and CD4+CD45RClow (Th2-like) cell types. CD45 extracellular domain is able to interact with a number of different proteins including CD4, TCR, CD2, Thy-1 and CD26. CD45 is important for signalling throguh the T cell receptor and in the selection of T and B lymphocytes. |
| Application Notes: | OX-20 can be used for both FC and IHC (paraffin/frozen) studies. It can also be used to purify proteins by affinty-purification (Woolett et al. Eur J Immunol. 1985 Feb;15(2):168-73). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |