Mfg Part Number
Ab00570-1.1
Vector Labs Ab00570-1.1 Anti-CD47 [OX-101], Mouse IgG1, kappa (200 μg)
Quick Overview
OX-101 was prepared by immunizing BALB/c mice with biotinylated rat thymocytes - this antibody was selected from a number of antibodies raised by the immunogen.
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| Product Class: | Purified |
|---|---|
| Clone ID: | OX-101 |
| Synonyms: | IAP; OX101; MRC OX-101; MRC OX101; leukocyte surface antigen CD47; integrin-associated protein; intergin associated protein |
| Amount: | 200 μg |
| Application Codes Clone: | IP; FC; WB; block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | OX-101 binds specifically to CD47 and has been shown to compete with OX-41 for binding . CD47 acts as an adhesionn receptor for THBS1 on platelets and is involved in the modulation of integrins (signalling). Acts as a SIRPA receptor - SIRPA binding prevents maturation of immature dentritic cells and and inhibits cytokine production by mature dendritic cells. Possibly involved in changes to membrane permeability due to virus infection. |
| Application Notes: | This antibody can be used for affinity chromatography purification and can block the interaction between OX41-CD4d3+4 beads and cells. In addition OX-101 can be used for FC and WB. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |