Mfg Part Number
Ab00578-2.3
Vector Labs Ab00578-2.3 Anti-CD147 [OX-114], Mouse IgG2a, Fc Silent™, kappa (200 μg)
Quick Overview
OX-114 was generated by immunizing rats with recombinant mCD147d0-2rCD4d3+4.
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| Product Class: | Purified |
|---|---|
| Clone ID: | OX-114 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Basigin; basic immunoglobulin superfamily; HT7 antigen; membrane glycoprotein gp42; gp42; gp-42; OX114; MRC OX-114; MRC OX114 |
| Amount: | 200 μg |
| Application Codes Clone: | WB; IHC; FC; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | OX-114 binds to both the 2- and 3-domain isoforms of CD147. CD147 targets monocarboxylate transporters to the plasma membrane, and is involved in spermatogenesis, embryo implantation, neural network fomration and tumor progression. Stimulates production of matrix metalloproteases. Possibly a receptor for oligomannosidic glycans. CD147 found only in vascular endothelium in non-neoplastic regions of the brain whereas it is present in tmour cells but not in proliferating blood vessels in malignant gliomas. |
| Application Notes: | This antibody binds mouse CD147, and has been used in FC and IHC-fr analysis to characterise CD147 and detect the cell types on which it is expressed, indicating that CD147 is a lymphocyte activation marker (Paterson, 1987). This antibody failed to give immunoprecipitates from radiolabelled activated T cells. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |