Mfg Part Number
Ab00592-3.0
Vector Labs Ab00592-3.0 Anti-CD43 [OX-56], Mouse IgG2b, kappa (200 μg)
Quick Overview
OX-56 was prepared by immunizing BALB/c mice with activated rat T lymphocytes.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | OX-56 |
| Synonyms: | Leukosialin; OX56; MRC OX-56; MRC OX56; sialophorin |
| Amount: | 200 μg |
| Application Codes Clone: | WB; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | OX-56 binds specifically to CD43 and binding is not affected by CD43 glycosylation. OX-56 reacts with most thymocytes and T lymphocytes in the lymph node cell population. This antibody also binds to pre-B cells and can detect CD43 at low levels on B cells. CD43 plays a role in the physicochemical properties of the T-cell surface and in lectin binding. CD43 is a major cell-surface sialoglycoprotein - also found on neutrophils, bone marrow stem cells, B-lineage cells after activation of thymocytes and T lymphocytes but is not expressed on resting B lymphocytes. The protein presents carbohydrate ligands to selectins and Is a counter-receptor for SN/Siglec-1. During T-cell activation it is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response. |
| Application Notes: | OX-56 has been used in the purification of rat leukosialin by immunoaffinty chromatography (Willis et al. 1987) as well as in WB. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |