Mfg Part Number
Ab00594-23.0
Vector Labs Ab00594-23.0 Anti-CD4 [YKIX302.9], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was prepared by immunizing rats with concanavilin A activated T-cell blasts
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | YKIX302.9 |
| Synonyms: | Leu3/T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IHC; IHC-fr |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the canine CD4 cell surface antigen, which, in contrast to other mammals, is expressed by neutrophils as well as lymphocyte subsets. |
| Application Notes: | This antibody recognizes canine CD4, which binds MHC II, and has been shown to block MHC II-dependent T cell responses in vivo and in vitro. In a canine transplant model, administration of this antibody has been demonstrated to partially deplete circulating T lymphocytes, but alone was not sufficient to prolong allograft survival (Watson, 1993). This antibody is one of a panel of anti-canine monoclonal antibodies can be used in the evaluation of leukemic status in dogs. This antibody has been used in IF and IP analysis to identify the canine homologue of human CD4 (Cobbold, 1994). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |