Mfg Part Number
Ab00596-7.4
Vector Labs Ab00596-7.4 Anti-CD44 [YKIX 337.8.7], Rat IgG2a, Fc Silent™, kappa (200 μg)
Quick Overview
YKIX 337.8.7 was prepared by immunizing rats canine thymocytes.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | YKIX 337.8.7 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | HCAM; CD44 antigen; extracellular receptor III; ECMR III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; HUTCH I; HUTCH 1; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; PGP-1; PGP 1; PGP I |
| Amount: | 200 μg |
| Application Codes Clone: | FACS; IHC; IP; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | YKIX 337.8.7 specifically binds to CD44. CD44 has high affinity for hyaluronic acid (HA) and can mediate cell-cell and cell-matrix interactions through its affinity for HA (and possibly also osteopontin, collagens, and matrix metalloproteinases (MMPs)). Adhesion with HA is important for cell migration, tumor growth and progression. CD44 also plays a role in lymphocyte activation, recirculation and homing, and in hematopoiesis. CD44 is a receptor for LGALS9 - this interaction enhances SMAD3 binding to the FOXP3 promoter, up-regulating FOXP3 expression and increasing induced regulatory T (iTreg) cell stability and suppressive function. |
| Application Notes: | YKIX 337.8.7 antibody can be used for IHC-Fr; YKIX 337.8.7 to distinguish CD4+ T-cell subsets. This antibody can additionally be used for FACS and IP. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |