Mfg Part Number
Ab00605-23.0
Vector Labs Ab00605-23.0 Anti-PCNA [PC10], Rabbit IgG, kappa (200 μg)
Quick Overview
Protein A-PCNA fusion obtained from pC2T.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | PC10 |
| Synonyms: | Proliferating cell nuclear antigen; cyclin or polymerase delta accessory protein |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IHC; IF; IP; WB |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds to PCNA from various vertebrate, invertebrate and fungal species. |
| Application Notes: | PCNA, also known as polymerase delta auxiliary protein, is essential for DNA replication and is involved in DNA excision and mismatch repair pathways. PCNA binds to the CDK inhibitor p21, the structure-specific endonucleases Fen1 and XPG, and DNA cytosine 5-methyltransferase (MCMT). PCNA is potentially a therapeutic target in cancer therapy and a useful marker for identifying the proliferation status of tumour tissue (i.e. relevant to prognosis). This antibody can be used for grading of different neoplasms, e.g. astrocytoma. It can be of diagnostic and prognostic value. Recommended for use on formalin-fixed paraffin embedded sections. NEUTRAL ELUTE ONLY. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |