Mfg Part Number
Ab00623-2.0
Vector Labs Ab00623-2.0 Anti-CD105 [MJ7/18], Mouse IgG2a, kappa (200 μg)
Quick Overview
MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
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| Product Class: | Purified |
|---|---|
| Clone ID: | MJ7/18 |
| Synonyms: | Endoglin; Cell surface MJ7/18 antigen |
| Amount: | 200 μg |
| Application Codes Clone: | FC; WB; IP; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | MJ7/18 binds specifically to mouse CD105. CD105 is a homodimer expressed by vascular endothelial cells. CD105 functions in adhesion and embryonic angiogenesis. CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. |
| Application Notes: | MJ7/18 can be used for FC, WB, IP and IHC (Baluk P, et al. 2003. Am. J. Pathol. 163:1801). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |