Mfg Part Number
Ab00627-23.0
Vector Labs Ab00627-23.0 Anti-Integrin beta-7 [FIB27], Rabbit IgG, kappa (200 μg)
Quick Overview
FIB27 was prepared by immunizing rats with TK1 cells.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | FIB27 |
| Synonyms: | FIB-27; FIB 27; Fib-27; Fib27; Fib 27; fib27; fib-27; fib 27; Integrin b7; integrin b-7; ITGB7; Gut homing receptor beta subunit |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IP; block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta-7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis. |
| Application Notes: | FIB27 can be used for FC, IP and can block TKI cell aggregation and beta-7 intergrin-mediated cell adhesion. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |