Mfg Part Number
Ab00670-1.32-BS
Vector Labs Ab00670-1.32-BS Anti-CD27 [LG.3A10], Mouse IgG1-D265A, Fc Silenced, kappa (1 mg)
Quick Overview
This antibody was produced by injecting Armenian hamsters intraperitoneally with a mixture of two murine CD27 tag-expressing Armenian hamster fibroblast clones (AR0524 and AR0530) in Freund's adjuvant
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| Product Class: | Purified |
|---|---|
| Clone ID: | LG.3A10 |
| Heavy Chain Modification: | Fc Silenced |
| Synonyms: | TNFRS7; CD27L receptor; T-cell activation antigen CD27; Tumor necrosis factor receptor superfamily member 7 |
| Amount: | 1 mg |
| Application Codes Clone: | Activating; IP; IF; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Hamster IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for mouse CD27, which, as in the human system, is largely restricted to cells of the T cell lineage, and is expressed on the great majority of both αβ and γδ T lymphocytes, and thymocytes. |
| Application Notes: | This antibody is specific for murine CD27, and has been used to assess the distribution of CD27 expression using IF, FC and IP analysis (Gravstein, 1995). Upon cross-linking, this antibody has been shown to induce a 4-fold increase in T cell proliferation in response to suboptimal stimulation with concanavalin A (Gravestein, 1995), indicating that this antibody is able to mimic ligand binding. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |