Mfg Part Number
Ab00718-10.3
Vector Labs Ab00718-10.3 Anti-TNF alpha [D2E7 (Adalimumab)], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | D2E7 (Adalimumab) |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Tumor necrosis factor alpha |
| Amount: | 200 μg |
| Application Codes Clone: | Blocking; ELISA; IHC; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. |
| Specificity Statement: | Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta). |
| Application Notes: | Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |