Mfg Part Number
Ab00729-200.0
Vector Labs Ab00729-200.0 Anti-RSV [RSHZ19 (Felvizumab)], Ferret IgA, (50 μg)
Quick Overview
This antibody was prepared by the humanization of an F protein-specific murine MAb, RSV19. More specifically, molecular techniques were used to insert the complementarity determining regions from murine RSV19 into a human IgG1 heavy and k light chain-variable domain framework.
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| Product Class: | Purified |
|---|---|
| Clone ID: | RSHZ19 (Felvizumab) |
| Synonyms: | SB 209763; respiratory syncytial virus |
| Amount: | 50 μg |
| Application Codes Clone: | functional; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric ferret antibody was made using the variable domain sequences of the original humanized Mouse format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the an epitope located between amino acids 417-432 of conserved fusion (F) protein of RSV. |
| Application Notes: | Though shown to be safe and well-tolerated (Everitt, 1996) and protective against RSV infection in BALB/c mice and cotton rats (Wyde, 1995), this antibody did not demonstrate efficacy in a Phase 3 study (Reichert, 2008). In in vitro studies, palivizumab, another humanized Mab specific for the F protein of RSV, was 4 to 5-fold more potent than |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |