Mfg Part Number
Ab00730-10.6
Vector Labs Ab00730-10.6 Anti-CD33 [SGN-33 (Lintuzumab)], Human Fab fragment, His-Tagged, kappa (200 μg)
Quick Overview
This humanized antibody was prepared by combining the CDR regions of the murine anti-CD33 M195 with human framework and constant regions.
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| Product Class: | Purified |
|---|---|
| Clone ID: | SGN-33 (Lintuzumab) |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | Sialic acid-binding Ig-like lectin 3; gp67; HuM195 |
| Amount: | 200 μg |
| Application Codes Clone: | functional |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 1737932 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for human CD33, which is restricted to cells of the myelomonocytic lineage. CD33 but does not appear in abundance on normal cells, but is over-expressed in AML and other myeloproliferative diseases. |
| Application Notes: | In vitro, this antibody is capable of mediating ADCC against AML cells (Caron, 1998). Though shown to be safe in phase III trials, the use of this antibody in combination with induction chemotherapy did not result in a statistically significant improvement in response rate or survival in patients with refractory/relapsed AML (Feldman, 2005). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |