Mfg Part Number
Ab00735-10.0
Vector Labs Ab00735-10.0 Anti-ADAMts13 [1-420 scFv], Human IgG1, kappa (200 μg)
Quick Overview
1-420 scFv was generated from a phage display library derived from human TTP patients expressing autoantibodies against ADAMTS13.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 1-420 scFv |
| Synonyms: | vWF-CP; ADAM-TS13; ADAMTS-13; C9orf8; VWFCP; ADAM metallopeptidase with thrombospondin type 1 motif 13 |
| Amount: | 200 μg |
| Application Codes Clone: | Inhibition |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 4534270 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | Binds to the ADAMTS13 spacer domain. 1-420 binds to the same ADAMTS13 spacer domain loop segments that are required for binding of ADAMTS13 to VWF. ADAMTS13 is a zinc-containing metalloprotease which is secreted in blood where it is able to cleave VWF, a protein involved in blood clotting, to decrease the protein's activity. |
| Application Notes: | Mice transfected with the scFv show ADAMTS13 inhibition and accumulation of unprocessed UL-VWF (ultralarge VWF) multimers. 1-420 mediates inhibition by binding to the same spacer domain loop domain segments required for ADAMTS13 binding to VWF. Please note that this antibody is subject to a pending patent application by the The Trustees Of The University Of Pennsylvania (WO2016164468 A2). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |