Vector Labs Ab00742-23.0 Anti-Tenascin [I-81C6 (Neuradiab)], Rabbit IgG, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: I-81C6 (Neuradiab)
Synonyms: Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C
Amount: 200 μg
Application Codes Clone: ELISA; radioiodination; immunoreactivity; cross-competition assay
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for tenascin, which is expressed in restricted locations in normal adult liver, kidney, spleen, and papillary dermis. However, tenascin has been shown to have increased stromal expression in breast carcinomas, gliomas, and prostatic carcinomas. Consequently, this antibody reacts with most human glioma cell lines, xenografts, and biopsy tissue, but not with normal brain tissue.
Application Notes: This I-labelled murine antibody binds tenascin, which is over expressed in certain cancers, and as a result has been used to deliver a radiation boost to the surgically created resection cavity (SCRC) margin; administration of a patient-specific radioactivity dose of this antibody into the SCRC enabled the consistent achievement of a 44-Gy boost to the SRC 2cm margin, associated with reduced neurotoxicity and improved survival relative to fixed dosing approaches (Reardon, 2008). In addition, a humanized form of this I-labeled murine antibody, generated by joining the 81C6 variable regions to the constant region of human IgG2, has been characterised through binding assays, cross-competition assays and immunoreactivity analysis, and has exhibited superior uptake in human glioma xenografts compared with its murine 81C6 parent (Zalutsky, 1996).

Product Class:	Purified
Clone ID:	I-81C6 (Neuradiab)
Synonyms:	Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C
Amount:	200 μg
Application Codes Clone:	ELISA; radioiodination; immunoreactivity; cross-competition assay
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for tenascin, which is expressed in restricted locations in normal adult liver, kidney, spleen, and papillary dermis. However, tenascin has been shown to have increased stromal expression in breast carcinomas, gliomas, and prostatic carcinomas. Consequently, this antibody reacts with most human glioma cell lines, xenografts, and biopsy tissue, but not with normal brain tissue.
Application Notes:	This I-labelled murine antibody binds tenascin, which is over expressed in certain cancers, and as a result has been used to deliver a radiation boost to the surgically created resection cavity (SCRC) margin; administration of a patient-specific radioactivity dose of this antibody into the SCRC enabled the consistent achievement of a 44-Gy boost to the SRC 2cm margin, associated with reduced neurotoxicity and improved survival relative to fixed dosing approaches (Reardon, 2008). In addition, a humanized form of this I-labeled murine antibody, generated by joining the 81C6 variable regions to the constant region of human IgG2, has been characterised through binding assays, cross-competition assays and immunoreactivity analysis, and has exhibited superior uptake in human glioma xenografts compared with its murine 81C6 parent (Zalutsky, 1996).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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