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Mfg Part Number

Ab00744-10.6-BS

Vector Labs Ab00744-10.6-BS Anti-NCAM-L1 [H2 scFv], Human Fab fragment, His-Tagged, lambda (1 mg)

VECTOR LABS

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Quick Overview

single-chain variable fragment antibodies against mouse L1 from a human synthetic phage display library.

$5,162.30

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Description

Product Class: Purified
Clone ID: H2 scFv
Heavy Chain Modification: His-Tagged
Synonyms: CD171; L1; Neural cell adhesion molecule L1; N-CAM-L1; L1
Amount: 1 mg
Application Codes Clone: ELISA; activate; WB; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: scFv
Storage Temperature: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This scFv binds specifically to the fibronectin type III repeats 1–2 of mouse L1 with a KD of around 2μM (determined by ELISA). It does not cross-react with human L1 in ELISAs, Western blots or immunofluorescence staining of cultured neurons. L1 plays important roles in cell adhesion, neuronal migration, neurite outgrowth, fasciculation and pathfinding, neuronal survival, and synaptic plasticity. L1 is not recongised under reducing conditions. L1 is a membrane glycoprotein of the immunoglobulin superfamily. Its interacts with adhesion molecules and proteins of the ECM. L1 also is inolved in the migration of cerebellar granule cells, enhancing neuronal survival and memory.
Application Notes: This scFv can stimulate neurite outgrowth from cerebellar dorsal, rootganglion and motor neurons and also be used to enhance survival of cerevellar neurons by facilitating the clustering of L1. H2 can also be used for ELISA, WB and IF studies.

Product Class:	Purified
Clone ID:	H2 scFv
Heavy Chain Modification:	His-Tagged
Synonyms:	CD171; L1; Neural cell adhesion molecule L1; N-CAM-L1; L1
Amount:	1 mg
Application Codes Clone:	ELISA; activate; WB; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	scFv
Storage Temperature:	Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This scFv binds specifically to the fibronectin type III repeats 1–2 of mouse L1 with a KD of around 2μM (determined by ELISA). It does not cross-react with human L1 in ELISAs, Western blots or immunofluorescence staining of cultured neurons. L1 plays important roles in cell adhesion, neuronal migration, neurite outgrowth, fasciculation and pathfinding, neuronal survival, and synaptic plasticity. L1 is not recongised under reducing conditions. L1 is a membrane glycoprotein of the immunoglobulin superfamily. Its interacts with adhesion molecules and proteins of the ECM. L1 also is inolved in the migration of cerebellar granule cells, enhancing neuronal survival and memory.
Application Notes:	This scFv can stimulate neurite outgrowth from cerebellar dorsal, rootganglion and motor neurons and also be used to enhance survival of cerevellar neurons by facilitating the clustering of L1. H2 can also be used for ELISA, WB and IF studies.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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