Mfg Part Number
Ab00760-1.1
Vector Labs Ab00760-1.1 Anti-Crotoxin [CTX-scFv8], Mouse IgG1, lambda (200 μg)
Quick Overview
scFv 8 was constructed from a phage display library using V-genes from 43 non-immunized donors.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CTX-scFv8 |
| Synonyms: | Phospholipase A2 crotoxin basic chain; CB; svPLA2; Cdcum6; Phosphatidylcholine 2-acylhydrolase |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; neutralize |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 10736105 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | scFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This full-length, chimeric mouse antibody was made using the variable domain sequences of the original Human scFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | scFv binds to crotoxin and recognises epitopes overlapping BI-a (an epitopic region at the interface between the CA and CB subunits of the heterodimer) and BIII (an epitopic region on CB involved in the enzymatic activity of CB) - scFv 8 may be able to caused the two subunits to dissociate and suppress the synergistic activity between them. Crotoxin is a phospholipase A2 neurotoxin and is the main toxic component in venome from Crotalus durissus terrificus rattlesnakes, acting by blocking neuromuscular transmission. |
| Application Notes: | scFv 8 is able to reduce the myotoxicity induced by crotoxin and is able to neutralize the lethality induced by the toxin. This scFv was also used for (competitive ELISAs). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |