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Mfg Part Number

Ab00771-1.1

Vector Labs Ab00771-1.1 Anti-Junin virus GP1 [GD01], Mouse IgG1, kappa (200 μg)

VECTOR LABS

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Quick Overview

The original antibody was generated by immunizing BALB/c mice with inactivated-virus-infected BALB/c suckling mouse brain emulsion.

$517.40

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Description

Product Class: Purified
Clone ID: GD01
Synonyms: JUNV; GP1; JUNV GP1; GPC; Glycoprotein G1; Pre-glycoprotein polyprotein GP complex; Argentinian mammarenavirus; glycoprotein receptor-binding subunit 1; surface envelope glycoprotein; Pre-GP-C; GD01-AG02; J200
Amount: 200 μg
Application Codes Clone: ELISA; WB; IP; IF; neutralize; Crystallization
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the GP1 subunit of the JUNV surface envelope glycoprotein GPC.
Application Notes: The original version of this antibody (mouse IgG2a) successfully bound Junin virus (XJ45 strain) GP1 in an ELISA. This antibody was used for the indirect immunofluorescent staining of Junin virus-infected Vero cells. This antibody reacted with Junin GP1 in immunoprecipitation and western blot. This antibody successfully neutralized the Junin virus in an in vitro assay (Sanchez et al., 1989; PMID: 2471803). The GP1-bound Fab version of this antibody was crystallized, and its structure was determined. This antibody neutralized the active form of JUNV by disrupting the interaction between GP1 and TfR1. A competition assay showed that IgGs from survivors of AHF did not compete with this antibody (Mahmutovic et al., 2015; PMID: 26651946). This antibody exhibited potent neutralization of the Candid #1 JUNV strain in a plaque neutralization assay (Zeitlin et al., 2016; PMID: 27044104).

Product Class:	Purified
Clone ID:	GD01
Synonyms:	JUNV; GP1; JUNV GP1; GPC; Glycoprotein G1; Pre-glycoprotein polyprotein GP complex; Argentinian mammarenavirus; glycoprotein receptor-binding subunit 1; surface envelope glycoprotein; Pre-GP-C; GD01-AG02; J200
Amount:	200 μg
Application Codes Clone:	ELISA; WB; IP; IF; neutralize; Crystallization
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the GP1 subunit of the JUNV surface envelope glycoprotein GPC.
Application Notes:	The original version of this antibody (mouse IgG2a) successfully bound Junin virus (XJ45 strain) GP1 in an ELISA. This antibody was used for the indirect immunofluorescent staining of Junin virus-infected Vero cells. This antibody reacted with Junin GP1 in immunoprecipitation and western blot. This antibody successfully neutralized the Junin virus in an in vitro assay (Sanchez et al., 1989; PMID: 2471803). The GP1-bound Fab version of this antibody was crystallized, and its structure was determined. This antibody neutralized the active form of JUNV by disrupting the interaction between GP1 and TfR1. A competition assay showed that IgGs from survivors of AHF did not compete with this antibody (Mahmutovic et al., 2015; PMID: 26651946). This antibody exhibited potent neutralization of the Candid #1 JUNV strain in a plaque neutralization assay (Zeitlin et al., 2016; PMID: 27044104).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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