Mfg Part Number
Ab00771-2.0
Vector Labs Ab00771-2.0 Anti-Junin virus GP1 [GD01], Mouse IgG2a, kappa (100 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with inactivated-virus-infected BALB/c suckling mouse brain emulsion.
$570.70
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| Product Class: | Purified |
|---|---|
| Clone ID: | GD01 |
| Synonyms: | JUNV; GP1; JUNV GP1; GPC; Glycoprotein G1; Pre-glycoprotein polyprotein GP complex; Argentinian mammarenavirus; glycoprotein receptor-binding subunit 1; surface envelope glycoprotein; Pre-GP-C; GD01-AG02; J200 |
| Amount: | 100 μg |
| Application Codes Clone: | ELISA; WB; IP; IF; neutralize; Crystallization |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for the GP1 subunit of the JUNV surface envelope glycoprotein GPC. |
| Application Notes: | The original version of this antibody (mouse IgG2a) successfully bound Junin virus (XJ45 strain) GP1 in an ELISA. This antibody was used for the indirect immunofluorescent staining of Junin virus-infected Vero cells. This antibody reacted with Junin GP1 in immunoprecipitation and western blot. This antibody successfully neutralized the Junin virus in an in vitro assay (Sanchez et al., 1989; PMID: 2471803). The GP1-bound Fab version of this antibody was crystallized, and its structure was determined. This antibody neutralized the active form of JUNV by disrupting the interaction between GP1 and TfR1. A competition assay showed that IgGs from survivors of AHF did not compete with this antibody (Mahmutovic et al., 2015; PMID: 26651946). This antibody exhibited potent neutralization of the Candid #1 JUNV strain in a plaque neutralization assay (Zeitlin et al., 2016; PMID: 27044104). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |