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Mfg Part Number

Ab00793-10.6

Vector Labs Ab00793-10.6 Anti-LPS [S20], Human Fab fragment, His-Tagged, kappa (100 μg)

VECTOR LABS

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Quick Overview

Ig-inactivated transgenic mice possessing human heavy and light Igs (strain XMG2) were immunized with heat-killed 06ad P. aeruginosa. The supernatants from the derived hybridomas were screened for IgG mAb production against the 06ad high molecular weight LPS O-side-chain using ELISA.

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Description

Product Class: Purified
Clone ID: S20
Heavy Chain Modification: His-Tagged
Synonyms: lipopolysaccharide; lipopolysaccharide O side chain
Amount: 100 μg
Application Codes Clone: Neutralize; ELISA
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: S20 binds to the polysaccharide (PS) portion of the lipopolysaccharide O side chain of a common pathogenic serogroup of P. aeruginosa, 06ad. The antibody also binds Fisher Devlin immunotype 1 P. aeruginosa, (considered part of the 06 serogroup) but there is no cross-reactivity with LPSs from other P. aeruginosa serotypes (strains IATS 011, IATS 016, 170003, and PAO1 Holloway). P. aeruginosa is a human pathogen, which poses a serious risk to individuals with weak immune systems. LPS is a serotypic marker present on the surface of the bacterium.
Application Notes: S20 human MAb is highly opsonic (complement-dependent) for the uptake and killing of live and heat-killed P. aeruginosa by fresh human PMN ( polymorphonuclear leukocytes). BALB/c mice rendered neutropenic challenged with 06ad P. aeruginosa saw 100% protection from mortality. S20 can also be used to detect 06ad LPS by ELISA.

Product Class:	Purified
Clone ID:	S20
Heavy Chain Modification:	His-Tagged
Synonyms:	lipopolysaccharide; lipopolysaccharide O side chain
Amount:	100 μg
Application Codes Clone:	Neutralize; ELISA
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	S20 binds to the polysaccharide (PS) portion of the lipopolysaccharide O side chain of a common pathogenic serogroup of P. aeruginosa, 06ad. The antibody also binds Fisher Devlin immunotype 1 P. aeruginosa, (considered part of the 06 serogroup) but there is no cross-reactivity with LPSs from other P. aeruginosa serotypes (strains IATS 011, IATS 016, 170003, and PAO1 Holloway). P. aeruginosa is a human pathogen, which poses a serious risk to individuals with weak immune systems. LPS is a serotypic marker present on the surface of the bacterium.
Application Notes:	S20 human MAb is highly opsonic (complement-dependent) for the uptake and killing of live and heat-killed P. aeruginosa by fresh human PMN ( polymorphonuclear leukocytes). BALB/c mice rendered neutropenic challenged with 06ad P. aeruginosa saw 100% protection from mortality. S20 can also be used to detect 06ad LPS by ELISA.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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