Mfg Part Number
Ab00814-1.32
Vector Labs Ab00814-1.32 Anti-ICOS [7E.17G9], Mouse IgG1-D265A, Fc Silenced, kappa (100 μg)
Quick Overview
Rats were immunized i.m. three times with 500 mg murine ICOS cDNA in the pAXEF mammalian expression vector and boosted twice with 200 mg murine ICOS hexahistidine fusion protein.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 7E.17G9 |
| Heavy Chain Modification: | Fc Silenced |
| Synonyms: | CD278; AILIM; CVID1; inducible T-cell co-stimulator; inducible T-cell costimulator; 7E.17G9.G1.G7 |
| Amount: | 100 μg |
| Application Codes Clone: | FC; Block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This anitbody binds to mouse ICOS (CD278). |
| Application Notes: | This antibody can be used to detect mouse ICOS by flow-cytometry. Maazi et al (2015, PMID: 25769613) showed that 7E.17G9 can inhibit ICOS interaction with its ligand ICOSL. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |