Mfg Part Number
Ab00817-2.3
Vector Labs Ab00817-2.3 Anti-BCR-ABL [7c6], Mouse IgG2a, Fc Silent™, kappa (200 μg)
Quick Overview
Murine antibodies were produced by immunising BALB/c mice with residues 686-696 (SSINEEITPRRQS) of human BCR fused to thyroglobulin. Hybridomas were generated by fusion of immunised cells with the myeloma cell line P3X63Ag8 via established methods.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 7c6 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | BCR/ABL; Breakpoint cluster region protein-tyrosine protein kinase ABL1 fusion protein |
| Amount: | 200 μg |
| Application Codes Clone: | IF; IHC; WB; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for the SSINEEITPRRQS epitope of BCR (residues 686-696), and as such is able to recognise full-length BCR and the p210 form of the BCR-ABL fusion protein. p210 BCR-ABL is a cytogenetic marker of chronic myelogenous leukaemia, resulting from gross chromosomal translocation resulting in the 'Philadelphia chromosome'. The fusion protein is a constitutively active tyrosine kinase, causing deregulated downstream signalling and increasing likelihood of oncogenic transformation. |
| Application Notes: | It has been shown by Western blot that 7c6 binds wildtype, full-length BCR and the p210 BCR-ABL fusion protein. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |