Mfg Part Number
Ab00831-10.3
Vector Labs Ab00831-10.3 Anti-CD72 [BU40], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised against the HF B1 plasmacytoid cell line, which is considered to be late B-like.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | BU40 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Lyb-2; B-cell differentiation antigen CD72 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; stimulatory; activate |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for CD72, which is highly expressed by pre-B cells and B-cells, but not terminally differentiated plasma cells. |
| Application Notes: | This antibody has been used to investigate cell-surface expression of CD72 in FACS analysis (Kataoka et al, 2013). This antibody has been shown to induce resting B cells to enter the G1 phase of the cell cycle, stimulate B cell expression of major histocompatibility complex class II antigen and potentiate the capacity of IL-4 to induce CD23 production (Katira et al, 1992). It also stimulates TNF-α and IL-6 production in CD14+ monocytes (Yoshida et al, 2015). Ligation of CD72 by this antibody has been observed to suppress the proliferation of an acute myelogenous leukaemia cell line (Kataoka et al, 2013). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |