Mfg Part Number
Ab00846-10.0
Vector Labs Ab00846-10.0 Anti-V(beta)3 TCR [JOVI.1], Human IgG1, kappa (200 μg)
Quick Overview
Thymus, spleen and mesenteric lymph nodes isolated from a mouse transgenic for human Vb3 TcR.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | JOVI.1 |
| Amount: | 200 μg |
| Application Codes Clone: | FACS; IHC; IF; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds to human V-beta 3 chain of the T-cell receptor. In particular this antibody binds to the TRBC1 variant but not the TRBC2 variant. |
| Application Notes: | This antibody can be used to detect the TCR beta chain in a majority (50-75%) of T-cell receptors by flow cytometry, immunofluorescence and can immunoprecipitate the TCR beta protein (variant 1). Recently it has been combined into a chimeric antigen antigen receptor therapy approach to selectively deplete a subset of T-cells in T-cell lymphomas or leukaemias, whilst leaving the non-reactive T-cell subset intact. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |