Mfg Part Number
Ab00891-1.1
Vector Labs Ab00891-1.1 Anti-alpha V beta 6 integrin [EM05201], Mouse IgG1, kappa (100 μg)
Quick Overview
This antibody was raised by immunising rabbits, isolating B cells from the immunised rabbits and fusing these with a rabbit plasmacytoma cell line (established by Spieker-Polet et al., 1995) to produce stable hybridomas
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| Product Class: | Purified |
|---|---|
| Clone ID: | EM05201 |
| Synonyms: | αvβ6; Vitronectin receptor subunit alpha; CD51; ITGB6; Integrin beta-6; P06756; P18564; avb6 |
| Amount: | 100 μg |
| Application Codes Clone: | IHC; WB; FC; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rabbit IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the extracellular domain of human recombinant transmembrane-truncated (DTM) αvβ6 integrin, a dimeric cell surface protein that mediates cell attachment. αvβ6 integrin promotes the activation of latent TGF-β. |
| Application Notes: | This antibody has been used to specifically bind αvβ6 in Western blots and in flow cytometry, and to specifically stain αvβ6 integrins in FFPE (formalin fixed paraffin embedded)/TMA material, where murine antibodies function poorly (Goodman et al, 2012; Heß et al., 2014; Roth et al, 2013). This revealed αvβ6 to be strongly expressed in samples of invasive ductal breast adenoma, colorectal carcinoma, and NSCLC. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |