Mfg Part Number
Ab00892-23.0
Vector Labs Ab00892-23.0 Anti-alpha V beta 8 integrin [EM13309], Rabbit IgG, kappa (100 μg)
Quick Overview
This antibody was raised by immunizing rabbits, isolating B cells from the immunized rabbits, and fusing these with a rabbit plasmacytoma cell line (established by Spieker-Polet et al., 1995) to produce stable hybridomas.
$692.90
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | EM13309 |
| Synonyms: | αvβ8; Vitronectin receptor subunit alpha; CD51; Integrin beta-8; ITGB8; P06756; P26012; avb8 |
| Amount: | 100 μg |
| Application Codes Clone: | IHC; WB; FC; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for the extracellular domain of human recombinant transmembrane-truncated (DTM) αvβ8 integrin, a dimeric cell surface protein that mediates cell attachment. αvβ8 integrin promotes the activation of latent TGF-β, as well as inhibiting tumor cell growth. |
| Application Notes: | This antibody has been used to specifically bind αvβ8 in Western blots and flow cytometry and to specifically stain αvβ8 integrins in FFPE (formalin-fixed paraffin-embedded) or TMA material, where murine antibodies function poorly (Goodman et al., 2012; PMID: 23213423) (Roth et al., 2013; PMID: 23378223) (Heß et al., 2014; PMID: 25305804). αvβ8 is weakly expressed in human tumor specimens and non-small-cell lung carcinoma, with some expression in ovarian carcinoma and melanoma cells. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |