Mfg Part Number
Ab00893-1.1
Vector Labs Ab00893-1.1 Anti-DARC [2C3], Mouse IgG1, kappa (200 μg)
Quick Overview
CHO cells transfected with cDNA encoding the Duffy glycoprotein.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 2C3 |
| Synonyms: | Fy6; Duffy Antigen Receptor for Chemokines; NaM185-2C3 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; FC; Blocking; Inhibition; WB |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 25706384 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | The antibody specifically binds to the pentapeptide FEDVW of the Duffy Antigen Receptor for Chemokines (DARC). The epitope is located on the N-terminal region on the RBC surface membrane. DARC is a glycoprotein chemokine receptor and the only known receptor for Plasmodium vivax. |
| Application Notes: | The original antibody (mouse IgG1) was generated and used successfully in ELISA, FC, and inhibition assays, blocking DARC and IL-8 binding. The antibody's epitope was also characterized (Wasniowska et al., 2002; PMID: 12164140). This antibody was successfully used in a WB (Czerwinski et al., 2007 (PMID: 17382291); Smolarek et al., 2015 (PMID: 25706384)). This antibody was successfully used to inhibit P. Vivax invasion (Russell et al., 2011 (PMID: 21768300); Urusova et al., 2019 (PMID: 31133752)). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |