Mfg Part Number
Ab00906-13.12
Vector Labs Ab00906-13.12 Anti-ZIKV soluble envelope protein [z23], Human IgG4-S228P, kappa (200 μg)
Quick Overview
This antibody was derived from memory B cells specific for purified monomeric Zika virus soluble envelope protein, which were isolated by FACS from the blood of a patient 20 days post-infection with zika virus. To generate full-length monoclonal antibodies, the variable regions were then cloned into human IgG1 constant region.
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| Product Class: | Purified |
|---|---|
| Clone ID: | z23 |
| Synonyms: | sE; ZIKV |
| Amount: | 200 μg |
| Application Codes Clone: | Block |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody bind a tertiary epitope in the zika virus soluble envelope protein domain III. |
| Application Notes: | This antibody specifically and potently neutralises Zika virus in vitro, and does not cross-react with strains 1 - 4 of dengue virus, which minimises the risk of antibody-dependent enhancement (Wang et al, 2016). In a murine model, this antibody confers postexposure protection against Zika virus (Wang et al, 2016). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |