Mfg Part Number
Ab00908-10.6-BS
Vector Labs Ab00908-10.6-BS Anti-CD146 [IR94], Human Fab fragment, His-Tagged, lambda (1 mg)
Quick Overview
This antibody was generated by phage display, during which phage were added to immunotubes coated in the MUC18 antigenic peptide. TG-1 bacteria were then infected by the phage before four rounds of panning were performed to select scFvs with high affinity and specificity for the MUC18 epitope.
$5,162.30
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| Product Class: | Purified |
|---|---|
| Clone ID: | IR94 |
| Heavy Chain Modification: | His-Tagged |
| Synonyms: | MUC18; melanoma cell adhesion molecule; MCAM; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen |
| Amount: | 1 mg |
| Application Codes Clone: | ELISA; WB; FC; inhibition |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | ScFv |
| Storage Temperature: | Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original ScFv format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for the Wnt-5a binding site on human MUC18. |
| Application Notes: | The specificity and cell surface binding ability of this scFv has been confirmed in ELISA, WB and FC analysis (Mohammadi et al, 2017). This scFv recognises cell surface receptor MUC18, expression of which is altered on epithelial tumors, playing an important role in metastasis. In in vitro assays, this scFv significantly inhibits the migration and invasion of an MUC18-expressing cell line (Mohammadi et al, 2017), and has the potential to be employed in breast cancer immunotherapy. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |