Mfg Part Number
Ab00912-2.3
Vector Labs Ab00912-2.3 Anti-ectodysplasin A [EctoD2], Mouse IgG2a, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunising Eda-deficient Tabby mice with an active recombinant form of EDA1 (Fc-EDA1).
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | EctoD2 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | O54693; Q92838; Ectodysplasin-A; EDA |
| Amount: | 200 μg |
| Application Codes Clone: | block; SDS-PAGE; WB; FC; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognises the conserved extracellular, receptor-binding region of murine, avian and human ectodysplasin-A. |
| Application Notes: | The specificity of this antibody for EDA has been confirmed in SDS-PAGE, Western blot, ELISA, native gel electrophoresis and FC experiments (Kowalczyk-Quintas et al, 2014). This antibody blocks mammalian and avian EDA1 and EDA2 from binding EDAR (Kowalczyk-Quintas et al, 2014). When administered to pregnant wild-type mice, this antibody induces foetal ectodermal dysplasia (Kowalczyk-Quintas et al, 2014). Therapeutically, this antibody may be useful in the treatment of disorders arising as a result of excessive EDA1 action. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |