Mfg Part Number
Ab00913-8.4
Vector Labs Ab00913-8.4 Anti-IL-2 [Jes6-1], Rat IgG2b, Fc Silent™, kappa (200 μg)
Quick Overview
Rat antibodies were raised against murine IL-2.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | Jes6-1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Interleukin-2; IL2; T cell growth factor; JES6-1A12 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IP; NTRL |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted rat antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody binds murine IL-2. |
| Application Notes: | JES6-1 is a scFv reformat of the variable domain sequences of the JES6-1 monoclonal antibody (Spangler et al, 2015). It was shown in this study that JES6-1 scFv binding to mouse IL-2 would sterically hinder interaction with the IL-2 receptor, thereby blocking downstream signalling functions. This antibody is well known as a neutralising antibody against mouse IL-2, and is useful for cytokine assays such as ELISA (Abrams et al, 1992). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |