Mfg Part Number
Ab00928-23.0
Vector Labs Ab00928-23.0 Anti-JMJD6 [APSR-14.4], Rabbit IgG, kappa (200 μg)
Quick Overview
APSR-14.4 was produced by immunising Armenian hamsters using human His-tagged JMJD6.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | APSR-14.4 |
| Synonyms: | HisArgDeMe; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Histone arginine demethylase JMJD6; Jumonji domain-containing protein 6; JmjC domain-containing protein 6; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine recep |
| Amount: | 200 μg |
| Application Codes Clone: | Crystallisation; WB; IP; IF |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 20679243 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | APSR-14.4 was shown crystallographically to bind the C-terminal helix-turn-helix domain of JMJD6 (Hong et al, 2010). JMJD6 was initially identified as a phosphatidylserine receptor, but is now known to be a multifunctional histone modifier which may also be implied in RNA splicing. JMJD6 expression levels have more recently been associated with poor outcomes in breast cancer tumours (Lee et al, 2012). |
| Application Notes: | The APSR-14.4 Fab region was used to facilitate crystallisation of JMJD6 (Hong et al, 2010). The mAb has also been used to identify JMJD6 both using Western blot as well as by immunofluorescent staining of of 293 cells (National Jewish Medical and |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |