Mfg Part Number
Ab00941-10.3
Vector Labs Ab00941-10.3 Anti-Envelope protein (soluble) [Z23], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
Anti-ZIKV mAbs were obtained from the sera and peripheral blood mononuclear cells of a ZIKV-infected patient.
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| Product Class: | Purified |
|---|---|
| Clone ID: | Z23 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | ZIKV sE; Zika virus soluble envelope protein; Zika virus envelope protein; ZIKV soluble envelope protein; ZIKV envelope protein; Zika virus sE protein; ZIKV sE protein; ZIKV sE; Z-23 |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; ELISA; FC; SPR |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 27974667 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | Z23 binds to the ZIKV soluble envelope (sE) protein, shown using ELISAs, SPR and kinetic competition assays (Wang et al, 2016). This mAb is highly specific for ZIKV, and was shown to exhibit no neutralisation activity against DENV-1 to DENV-4 virions, which are highly related to ZIKV. Z23 was shown to bind domain III of sE by cryo-electron microscopy. ZIKV has recently become a major global health concern, following a 2015 outbreak. Viral infection is associated with neurological complications and microencephaly. |
| Application Notes: | Z23 was confirmed to bind ZIKV sE protein by ELISA, with an affinity of 0.44 uM shown by SPR (Wang et al, 2016). Using a FACS-based assay, it was shown that Z23 potently neutralised viral activity against infected C6/36 and Vero cells. In vivo, Z23 completely protected IFN receptor KO mice from ZIKV infection. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |